Therapeutic Mechanisms
Visual explanations and articles on immune pathways, drug targets and mechanisms of action.
-
Cytokines at the Door: Welcome to Club Synovium
Inside RheumaView Learning Lab: meet Club Synovium, follow Club Enthesis in development, and discover an expanding world of interactive rheumatology education.
-
Beyond the Slide Deck: An Interactive Anti-BAFF-R Education Demo in Cascade™
See how a fictional anti-BAFF-R program demonstrates CASCADE’s clinical narrative, mechanism visualization, evidence interpretation and assessment.
-
Lupus Nephritis by Class
Explore the six classes of lupus nephritis and how immune-complex location in the glomerulus shapes biopsy findings and patterns of kidney injury.
-
The JAK Family: overview
Explore the four Janus kinases, cytokine receptor pairing and the signaling architecture behind targeted immune therapies.
-
The Lungs in Systemic Sclerosis: SSc-ILD and PAH
Watch a physician-authored overview of interstitial lung disease and pulmonary arterial hypertension in systemic sclerosis, with imaging and mechanism context.
-
CASCADE: preview
A brief preview of CASCADE’s interactive therapeutic education format, with clinical context and mechanism-based learning for professional audiences.
-
Sjögren’s Syndrome: from dryness to disease modification
Watch an educational film on Sjögren’s disease, unmet needs and investigational disease-modifying strategies, with a guide to what the film covers.
-
Psoriasis From the Inside Out: How the Plaque Forms, and Where Our Drugs Act
Follow the psoriatic plaque from immune signaling to skin change, with a short visual explanation of where targeted therapies intervene.
-
Silencing, Not Deleting: The Case for B-Cell Inhibitory Antibodies in Autoimmune Disease
Explore the rationale for CD19–FcγRIIb co-engagement and inhibitory B-cell signaling as a distinct approach to autoimmune disease therapy.
-
CASCADE page updated — TYK2 mechanism-of-action film added
Explore CASCADE’s brand-neutral TYK2 animation, tracing cytokine signaling and selective allosteric inhibition at the JH2 domain.
Rheumatology is the art of suspecting inflammation. Radiology is the art of waiting until it finally agrees to be seen.
Rheumatology diagnoses the argument. Radiology waits for the evidence to calcify.